FREE RADICALS AND CARDIACGLYCOSIDE-INDUCED CARDIOTOXICITY
- VernacularTitle:自由基与强心甙的心脏毒性
- Author:
Zifang CHEN
;
Xiaoling JI
;
Qian LUO
- Publication Type:Journal Article
- Keywords:
Free radicals;
Cardiacglycoside;
Arrhythmia;
ESR
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The models of Cardiacglycoside-induced cardiotoxicity in guinea pigs were made by perfusing isolated heart with Langendorff appa- ratus. The free radicals generation in myocardium following the incidence of ventricular premative beat, ventricular tachycardia and ventricular fibrillation were measured respectively by the directed measurement with Electron Spin Resonance ( ESR ) techniques. The results showed the more severe toxicosis, the more much free radicals generate. Free radicals generated significantly in ventricular fibrillation and were scavenged by Superoxide dismutase ( SOD ) and sodium selenate.
