THE PROTECTIVE EFFECTS OF NIFEDIPINE, ASPIRIN AND NIFEDIPINE COMBINED WITH ASPIRIN ON ACUTE MYOCARDIAL ISCHEMIA INDUCED BY PITUITRIN IN RATS
- VernacularTitle:硝苯吡啶、阿斯匹林及两者并用对大鼠急性心肌缺血的保护作用
- Author:
Huagang HOU
;
Chuiying XU
;
Shan SHI
- Publication Type:Journal Article
- Keywords:
Aspirin;
Nifedipine;
Pituitrin;
Acute myocardial ischemia
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The protective effects of Nifedipine, Aspirin and Aspirin combined with Nifedipine on acute myocardial ischemia induced by pi-tuitrin in rats were studied, when 20% Alcohol (2ml/kg), Nifedipine (0.05 mg/kg) and Aspirin (0.025mg/kg) was singly used, no remakable effects were observed on the indexes of ischemic ECG of the experimental rats. When Nifedipine (0.1mg/kg) or Aspirin (0.05mg/kg) was used singly, or they were used in combination (0.05 + 0.025mg/kg ); The significant counteractions were observed on the changes in ST segments and T waves in the first and second phases of the rats ECG caused by pituitrin, and the occurrence of decrease of heart rate and arrhythmia were prevented. The doses were correlated with the effects. The two drugs used in combination showed noticeable synergism.
