EFFECTS OF NATIVE ISOSORBIDE MONONITRATE ON HEMODYNAMICS IN RATS WITH MYOCARDIAL INFRACTION
- VernacularTitle:国产单硝酸异山梨醇酯对心肌梗塞大鼠血液动力学的影响
- Author:
Liang TAO
;
Qiquan JIN
- Publication Type:Journal Article
- Keywords:
Isosorbide mononitrate;
Myocardial infraction;
Cardiac function
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Tho effects of native isosorbide mononitrate ( ISMN ) on the hemodynamics in rats with early myocardial infarction by left coronary artery occlusion were investigated. LVSP and dP/dtMAX were increased, and LVEDP was decreased with ISMN 5mg/kg i.v. 20 min after coronary occlusion. However, ISMN did not significantly effect the HR, SAP, DAP and MAP. The results showed that ISMN can improve cardial function in early myocardial infarction.
