STUDIES OF CARBAMAZEPINE CONCENTRATION AND TOXIC AND SIDE REACTIONS IN ANTIEPILEPTIC THERAPY
- VernacularTitle:酰胺咪嗪的浓度及抗癫痫治疗中毒副反应的研究
- Author:
Ximei HE
;
Wei ZHOU
- Publication Type:Journal Article
- Keywords:
Carbamazepine;
Concentration;
Antiepilepsy;
Toxic and side reaction
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Carbamazepine ( CBZ ) serum and salivary concentration and toxic and side reactions were studied in 60 epilepsy patients. The propriate CBZ serum concentration was l7~38?mol/L, salivary concentration was 4~13?mol/L. The toxic and side reactions were correlated with serum level, there were different toxic symptoms when CBZ levels were in therapeutic range. When CBZ serum concen tration was higher than 38~51 ?mol/L, salivary concentration was higher than 14.8~17 ?mol/L, the toxic and side reactions were significant increased in our test patients.
