Study on Gucocorticoid Receptor in Rats with Traumatic Brain Edema
- VernacularTitle:大鼠创伤性脑水肿脑胞液中糖皮质激素受体的变化
- Author:
Qinzhi GONG
;
Cheng ZHU
;
Renbao XU
;
Zhongjian YANG
;
Jinxing TAN
;
Yingying LE
- Publication Type:Journal Article
- Keywords:
brain injuries, acute;
brain edema;
receptors, glucocorticoid;
disease models, animal;
rats
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The high-affinity glucocorticoid binding sites (HAGS) and the low-affinity glucocorticoid binding sites (LAGS) with steroid specificity were demostrated in cerebral cytosol of rats by using the radioligand binding assay. The Kd of HAGS and LAGS were (178?0.71)?l0-8mol/L and (2.12?1.06)?10-6mol/L respecitively as estimated by Scatchard and Pseudoscatchard analysis. Glucocorticoid receptors (GR) in the traumatized(left) hemisphere cytosol were decreased more significantly than those in both the control (right) hemisphere cytosol at 6h postinjury and normal brain tissue (P