Changes of Hearing Threshold Shift in Guinea Figs after Inhalation of Different Doses of Toluene
- VernacularTitle:豚鼠吸入不同剂量的甲苯引起的听阈偏移
- Author:
Qing YE
;
Shuchang LU
;
Zhengyun HU
;
Jiawen CHANG
- Publication Type:Journal Article
- Keywords:
toluene;
deafness;
evoked potential;
virulence;
ototoxicity;
guinea pigs
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Male guinea pigs were exposed to 750ppm or l000ppm or 1 500ppm toluene (8h/d, for 14d), and their hearing thresholds were tested by means of Madsen ERA 2250 system 3d and 14d after exposure. Hearing impairment was observed in all groups. The degree of impairment was related to the exposure concentration and had a tendency to further damage in two weeks. The results indicate that toluene can cause acute hearing impairment even if its concentration is as low as 750ppm and the impairment develops from bad to worse at least in two weeks.
