The Preparation of ~99mTc-NGA for Hepatocellular Receptor Imaging and Its Predinical Study in Rabbits
- VernacularTitle:肝受体显像剂~(99m)Tc-NGA的制备及临床前研究
- Author:
Lingshan KONG
;
Dengren XU
;
Wenzhou PAN
;
Jianxiong CHU
;
Hongxun LI
- Publication Type:Journal Article
- Keywords:
radionuclide imaging receptors;
ligands;
hepatoma
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Technetium-99m galactosyl-neoglycoalbumin (99mTc-NGA) is a new hepatocellular receptor imaging ligand Its preparation and preclinical research are reported in this paper. The ligand was synthesized by the chemical coupling and the product was nontoxic and apyrogenic with good stability both in vivo and in vitro. The static images and kinetic data obtained from the liver portal vein ligation group (n = 2), the hepatic necrosis group (n=2) and the control group (n=6) indicate: (1) Tc-NGA imaging can provide excellent hepatic images, and (2) hepatic kinetic data appear to provide a new means for diagnosis of liver diseases.
