The effects of diazepam on phenytoin pharmacokinetics in rabbits
- VernacularTitle:安定对兔体内苯妥因钠药代动力学的影响
- Author:
Shiwen ZHOU
;
Yuanyuan YANG
;
Retiming LIU
- Publication Type:Journal Article
- Keywords:
diazepam/PP;
phenytoin/ME;
kinetics;
rabbits
- From:Journal of Third Military Medical University
1984;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The serum level of intravenously dripped phenytoin was deter- mined in rabbits before and in different time intervals of a week after intramuscular injection of diazepam with fluorescence polarization immunoassay and the parameters were calculated on a microcomputer.It was found that in the 12th hour after diazepam injection,the serum level of phenytoin was significantly different from that of the control,and t1/2 of phenytoin was significantly prolonged;the model of pharmacokinetics of phenytoin was changed from one compartment open model to two compartment open model.Yet the AUC and Cl of phenytoin were not markedly altered.
