A study of renal functional damages due to chronic cadmium intoxication in rabbits
- VernacularTitle:慢性镉中毒肾功能损伤的研究
- Author:
Zhifen WU
;
Xiaolin JIN
;
Shenghua LIU
- Publication Type:Journal Article
- Keywords:
cadmium poisoning;
kidneys/IN;
rabbits;
enzyme repression
- From:Journal of Third Military Medical University
1984;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Rabbits were intoxicated with hypodermic injection of 0.8% CdCl2 in normal saline every other day for 3 months,and the blood level of urea nitrogen (BUN) and creatinine (Cr) and the activities of Na/K-ATpase,Ca-ATPase,and ?-GT in the renal cortex were determined.It was found that there were no remarkable changes of BUN and Cr level but significant reduction of the activities of the 3 enzymes.It is believed that the reduction of the enzyme activities is one of the factors to initiate the functional disturbances and morphological damages of the kidneys and plays an important role in the mechanism of renal failure if it is not promptly corrected.
