EFFECTS OF Cu~(2+) ON ISOLATED SUPERIOR CERVICAL SYMPATHETIC GANGLION OF RABBITS
- VernacularTitle:Cu~(2馺)对离体兔颈上交感神经节的作用
- Author:
Yinfu QI
;
Xiping CHE
- Publication Type:Journal Article
- Keywords:
Cu~(2+);
Sympathetic ganglia;
Action potentials;
Neostigmine;
L-cystein;
Sucrose-gap method
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of Cu2+ on superior cervical sympathetic ganglion of rabbits were studied by the sucrose-gap method. Cu2+ at cumula- tive concentration inhibited ganglion action potentials. IC50 of Cu2+ was 0.26 mmol/L. The effects of Cu2+ were antagonized by neostig-miae and L-cystein, while enhanced under 1/2[Ca2+] and reduced under 3[Ca2+] .Cu2+ inhibited ganglionic N wave and P wave,without affecting LN wave.
