EFFECTS OF ORIDONIN ON THE HEMODYNAMICS IN ANAESTHETIZED RABBITS
- VernacularTitle:冬凌草甲素对麻醉开胸家兔血流动力学的作用
- Author:
Qi LI
;
Zheng CHEN
;
Jie LIU
- Publication Type:Journal Article
- Keywords:
Oridonia;
Rabbit;
Hemodynamics
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Oridonin is ent-kaurane diterpenoid and is one of the efficacious component of Rabdosia Rubesecens ( Hemel. ) Hara in Henan province. In this experiment, the effects of Oridonin on hemody-namics of anaesthetized rabbits were studied. Hemodynamics effects of Oridonin (3.0 mg, 10.0mg/kg iv)were noticed. LVSP, ?dP/dt_max, Vpm, Lo, HR, SBP, DBF were decreased. t-dP/dt_max was increased. LVEDP did not changed. Oridonin decreased DBP more than SBP, it is suggested that Oridonin. may reduce vascular smooth muscle tone.
