THE PROTECTIVE EFFECTS OF TETRADRINE ON CEREBRAL ISCHEMIA
- VernacularTitle:粉防己碱对脑缺血的保护作用
- Author:
Songtao QI
;
Cheng ZHU
;
Yicheng LU
- Publication Type:Journal Article
- Keywords:
Tetradrine;
Cerebral ischemia;
Free radicaL;
Survival rate;
Rat
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The cerebral ischemia was produced by Pulsinellis method in Sparaque-Dawley rats. The brain edema and survival rate of rats with bilateral carotid and vertebral arteries occlusion for 60 min were observed in ip tetradrine at doses of 1 ~ 4 mg/kg groups and control rats.Superoxide dismutase and malondialdehyde in brain tissue were also measured by pyrogallol method and fluorescence spec-trometry. The results suggested that tetradrine have protective effect on cerebral ischemia, which was related to the inhibition of lipoxide and scavenging of oxygen free radical.
