EFFECTS OF MELATONIN AND SUPERNATANTS FROM CULTURED RATS PINEAL GLAND ON INTERLEUKIN 1 PRODUCTION
- VernacularTitle:褪黑素及松果腺培养上清对大鼠巨噬细胞产生IL-1的影响
- Author:
Wei WEI
;
Xuoguang CHEN
;
Junshan LIANG
- Publication Type:Journal Article
- Keywords:
Pineal gland;
Melatonin;
Interleukia 1
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Effects of melatonin ( MT ) and supernatants from cultured pineal glands stimulated by 10 ?mol/L isoproterenol (ISO) for 0, 30, 60, 120 min on interleukin I ( IL-1 ) production by peritoneal macrophage ( PM? ) in rats were studied. Theses results showed that LPS-induced IL-1 production by PM? was enhanced by in vitro treatment with MT (0.1~1 ?mol/L ) , but IL-1 production was not influenced by MT without LPS. LPS-induced IL-1 production by PM? was enhanced in various degree by the supernatants, action of supernatants for 60min was best. The data is suggested that LPS-activated M?s may be one of target cells for MT.
