The Effect of ~60Co?-ray on Antibody-secreting Cell and Its Dose-response Relation
- VernacularTitle:~(60)Co?线对抗体分泌细胞的作用及其剂量效应
- Author:
Chuansong CHEN
;
Yachun LI
;
Jianren XU
- Publication Type:Journal Article
- Keywords:
hybridoma cells;
monoclonal antibody;
radiation effect;
D37
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The mice B lymphocyte hybridoma cells were irradiated by 60Co?-rays with doses of 1, 2, 4, 6. 8Gy. A markedly dose-relation depression in cell survival rate, cell concentration and clone-forming rate was observed. D37 value of clone-forming rate was 8.26 Gy. Dose-relation depression was also observed in total production of monoclonal antibody of clones. But production of monoclonal antibody per clone was raised with radiation doses. These results indicate that ionization radiation depresses the survival activity of hybridoma cells, but stimulates the secretion of monoclonal antibody of survival cells.
