Expression of cancer gene products of IGF-Ⅱ, IGF-Ⅱ receptors, CSF-1 receptors in primary hepatic cancer and non-cancerous liver tissue
- VernacularTitle:肝癌、癌旁肝组织IGF-Ⅱ、IGF-Ⅱ受体及CSF-1受体/c-fms癌基因产物的表达
- Author:
Donghai YANG
;
Weiwen LIU
;
Jianren GU
- Publication Type:Journal Article
- Keywords:
hepatic cancer;
insulin-like growth factor II;
insulin-like growth factor II receptor;
colony-stimulating factor 1 receptor;
autocrine-stimuulated growthNote;
This work wass supporteq by the National "Seven Five" Research Fund of China and perform
- From:Journal of Third Military Medical University
1988;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The expression of cancer gene products of insuline-like growth factor Ⅱ (IGF-Ⅱ),IGF-Ⅱ receptors (IGF-Ⅱ-R),and colony-stimulating factor 1 receptors (CSF-1-R) /c-fms in 17 cases of human primary hepatic cancer,the non-cancerous liver tissue adjacent to the cancer,and normal liver tissue was studied with immunocytochemistry (ABC),Western blot and Northern blot techniques.It was found that the expression of IGF-Ⅱ,IGF-Ⅱ-R and CSF-1-R was significantly higher in the cancers than in normal liver tissues,and the expression of IGF-Ⅱ and IGF-Ⅱ-R was higher in the non-cancerous liver tissues than in the cancers.It was noteworthy that the expression of IGF-Ⅱ in both the cancerous and non-cancerous hepatic tissues was characterized by its fetal type.However the expression of CSF-1-R was distinctly higher in the cancers than in the non-cancerous hepatic tissue.These findings,the authors believe,imply that the aberrant overexpression of IGF-Ⅱ,IGF-Ⅱ-R and CSF-l-R might be related to the mechanism of auto-crine-stimulated growtth of the cells of human primary hepatic cancer.
