Effects of vasopressin on shuttle-box passive avoidance behavior in rats
- VernacularTitle:加压素对大鼠穿梭箱被动回避行为的影响
- Author:
Yusheng ZHOU
;
Changcheng ZHANG
- Publication Type:Journal Article
- Keywords:
vasopressin;
hydroxydopamines;
hippocampus;
memory;
behavior;
rat
- From:Journal of Third Military Medical University
1988;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Arginine-8-vasopressin (AVP) could promote the acquisition of shuttle-box passive avoidance behavior and delay the extinction of the behavior when injected into the hippocampus of rats.Intrahippocampal injection of 6-hydroxydopamine (6-OHDA) prevented AVP from enhancing memory.The authors had also observed that AVP could accelerate the degradation of cate-cholamine in the hippocampus when the contents of monoamine transmitters and their metabolites were analyzed with high-performance liquid chromatography and electrochemical detection. These facts suggest that vasopressin promotes the shuttle-box passive avoidance behavior in rats,strcnthens long-term memory as well as short-term memory,and exerts its effect on memory through its enhancing the degradation of norepinephrine and/or dopamine in the hippocampus.
