THE ANTITUMOR ACTION OF ADRIAMYCIN-POLY I:C COMPLEX IN VIVO AND IN VITRO
- VernacularTitle:Poly I:C作为阿霉素载体的研究
- Author:
Xiuguo ZHANG
;
Dezheng WU
- Publication Type:Journal Article
- Keywords:
Adriamycin;
Poly I:C;
Adriamycin-Poly I:C Complex
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The binding of adriamycin to poly I:C, a double-stranded thetic homoribopolymor,and antitumor activity of adriamycin-Poly I:C complex were studied. Results showed that the affinity for adriamycin to poly I:C is no linear relationship. Adriamycin binding rate( % ) = 20.6 + 0.2268?Poly I:C(W)/adriamycin(W)? The increased therapeu-tic effect of the complex was comparable to that of the free and the Poly I:C alone on bearing Sl80 mice. In vitro cytotoxic effect of the complex is lower than free adriamycin following lh exposure. The complex is recommended for clinical therapeutic studies.
