THE PHARMACOKINETICS OF DAURICINE IN RABBITS WITH EXPERIMENTAL ACUTE RENAL FAILURE OR ACUTE LIVER INJURY
- VernacularTitle:肝肾功能损害状态下蝙蝠葛碱的药动学
- Author:
Yaoting GUI
;
Zhongshun DAI
;
Fandian ZENG
;
Chongjia HU
- Publication Type:Journal Article
- Keywords:
Dauricine;
Pharmacokinetics;
Experimental acute renal failure;
Experimental acute liver injury
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Dauricine ( Dau ) was studied on the pharmacokinetics in experimental acute renal failure (ARF ) induced by HgCl2 or acute liver injury ( ALI ) induced by CC14 in rabbits.After iv administration of 5 mg/kg in normal rabbits the main pharmacokinetic parameters of Dau were as follows:t1/2=0.18?0.12 (h), t1/2?=3.18?0.95 ( h ) , Vd = 26.7l? 3.61 ( L/kg ) and Cl = 6.91 ? 1.74 ( L/h?kg-1 ). The pharmacokinetic parameters of Dau in ARF were not significantly different from that in normal. Cl (3.31?1.88 L/h?kg-1 ) in ALI was significantly lower than that in normal and t1/2? ( 8.85?4.57 h ) in ALI was considerably longer than that in normal.The results indicated that the pharmacokiaetics of Dau had no change in rabbits with ARF and its elimination was prolonged in rabbits with ALI.
