THE INFLUENCES OF AMMONIUM GLYCYRRHIZANATE AGON PROSTAGLANDIN(PG) AND DNA BIOSYNTHESIS IN CULTURED RAT AND HUMAN LYMPHOCYTES
- VernacularTitle:甘草酸单铵对体外培养人和大鼠淋巴细胞前列腺素和DNA合成的影响
- Author:
Jinhong DUAN
;
Jinxuan CHENG
;
Jiren CHENG
- Publication Type:Journal Article
- Keywords:
Ammonium Glycyrrnizanate ( AG );
3H-Thymidine ( 3H-TdR);
Lymphocytes;
Prostacycin ( PGI2 );
Thromboxane A2 (TXA2)
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The influences of varied concentrations of AG on the 8H-TdR(3H-Thymidine ) incorporation inhibition rate and the release of PGI2 and TXA2 were studied in cultured human and rat lymphocytes . The results indicated that the AG increased the 3H-TdR incorporation inhibition rate on the concentrations of 1.5? 10-7mol/L and 3?10-7mol/L. Using the RIA method, authors find that AG on the concentrations of 4 ? 10-7mol/L, 4 ? 10-3mol/L and 4 ? 10-11mo/L can significantly decrease the cultured lymphocytes TXA2 release while has no clear influences on PGI2 release
