BETA-ADRENERGIC RECEPTOR BLOCKING EFFECT OF BUNOLOL: A COMPARISON WITH PROPRANOLOL
- VernacularTitle:布诺洛尔和普萘洛尔对?肾上腺素受体阻断作用的比较
- Author:
Qiusheing TONG
;
Miyang SHI
;
Cheagbiao LU
;
Lina YAO
- Publication Type:Journal Article
- Keywords:
Bunolol;
Propranolol;
Atrium;
Trachea;
Beta-receptor blocking effect;
pA2
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The effect of bunolol on ?-adrenergic receptor of various tissues of animals were reported. The results showed that cumulative dose-response curves of isoprenaline were shifted paratlely to the right by bunolol ( 10-8, 10-7, 10-6mol/L ) on isolated rabbit atrium and guinea pig trachea preparation utilizing isoprenaline as a beta-receptor agonist. In the isolated rabbit right atrium preparation,the pA2 value of bunolol antagonizing the chronotropic action of isoprenaline was 9.3. In the isolated guinea-pig trachea preparation,the pA2 value of bunolol antagonizing the isoprenaline-induced relaxation was 9.1. By contrast, the 〔pA2 ( ?1 )- pA2 ( ?2 ) 〕 value of bunolol was 0.2, suggesting its ?-blocking action in the atrium being nearly 0,6 times more than that in the trachea. Also, comparison with pfopranolol, the blocking effect of bunolol on cardiac ?1 receptor and on trachea ?2 receptor were 4 times and 1.6 times more than that of propranolol respectively.Bunolol ( 1 mg/kg ) could, block completely the vasodilating response of epinephrine ( 10?gAg ) . At the same dosage, bunolol had no effect on blood pressure and heart rate of prior reserpini-sation rats.
