Role of Oxygen Radicals in Acute Lung Injury Induced by Burns Complicated by Cndotoxemia in Rats
- VernacularTitle:自由基在大鼠烫伤复合内毒素血症所致的急性肺损伤中的作用
- Author:
Huiqing SHENG
;
Xiaoqi GONG
;
Yafei ZHANG
- Publication Type:Journal Article
- Keywords:
lung injury;
burn;
endotoxemia;
MDA;
SOD
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
An animal model of acute lung injury was reproduced by intravenous injection of E. coli endotoxin to burned rats. The histological changes of lung were studied using transmission electron microscope. It was found that leukocytes accumulated in the pulmonary capillaries and adhered to endothelia. The WBC count decreased gradually. The level of MDA, lung coefficient and lung water content were increased. The SOD activity was decreased. Pretreatment with SOD could improve the changes mentioned above. This study suggests that oxygen radicals play an important role in acute lung injury induced by burns complicated by endotoxemia.
