A Study on Immunohistochemical Localization of Anti-human Osteosarcoma Monoclonal Antibodies in Osteogenic Sarcoma Tissues
- VernacularTitle:抗骨肉瘤单克隆抗体在骨肉瘤组织中的免疫组化定位研究
- Author:
Jianzhong BAO
;
Canrong NI
;
Cunzhong WU
;
Yimin DAI
- Publication Type:Journal Article
- Keywords:
osteosarcoma;
monoclonal antibody;
ABC immunohistochemical method
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Immunohistochemical localization of many sorts of tumor tissues from paraffin sections was studied using the ABC method with the monoclonal antibody secreted by the established two anti-osteosarcoma cell lines. It showed that the OS-McAb1 and OS-McAb2 had a negative reaction on the tested benign tumors and malignant tumors of epithelial tissue. Of the tested malignant tumors of mesenchyma, the antibodies had a positive reaction on some osteogenic sarcoma. They did not cross-react with various normal adult or fetal tissues, indicating that the OS-McAbs had a rather high specificity. They had a certain practical value in the immunopathologic diagnosis of malignant osteogenic tumors.
