Clinical observation on blood coagulation and fibrinolysis in acute leukemia
- VernacularTitle:急性白血病凝血与纤溶指标的临床观察
- Author:
Li WANG
;
Kunrong WANG
- Publication Type:Journal Article
- Keywords:
leukemia;
fibrinolysis;
hemorrhage
- From:Journal of Third Military Medical University
1988;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Plasma prekallikrein,total fibrinolytic activity (TFA),plasmi-nogen (PLG),fibrinogen (Fbg) and fibrin(ogen) degradation products (FDP) were determined with chromogenic peptide substrate (CPS) and routine hema-tologic methods in 20 patients with untreated acute leukemia.It was found that the activities of blood coagulation and fibrinolysis showed no significant difference between leukemic patients and the normal controls;marked elevation of FDP and Fbg was observed in leukemic patients;the activity of fibrinolysis was significantly higher in the leukemic cases with severe bleeding than in those cases with slight or little bleeding.In addition,a tendency of continuous lowering of FDP.and Fbg levels was observed in a dynamic observation of 3 acute leukemic cases.On the basis of these findings,it might be concluded that no activation of the fibrinolysis system occurs in most cases of acute leukemia;excessive fibrinolysis may be one of the factors to induce severe hemorrhage;the levels of FDP and Fbg are lower in the patients in remission stage than in those in active or relapse stage.Successive determination of FDP and Fbg levels is helpful to assess the conditions of a leukemic patient.
