PROTECTIVE EFFECTS OF GYPENOSIDES ON RAT HEPATIC LIPID PEROXIDATION AND MEMBRANE FLUIDITY DAMAGE: IN VITRO STUDIES
- VernacularTitle:绞股蓝总皂甙对离体大鼠肝脏脂质过氧化及膜流动性损伤的保护作用
- Author:
Lin LI
;
Shantian XING
;
Jinhuang ZHOU
- Publication Type:Journal Article
- Keywords:
Gypenoside;
Liver;
Lipid peroxidation;
Membrane fluidity
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The present in vitro study on rat liver microsomal lipid per-oxidation showed that Gypenosides ( GP ) , the total saponin of Gy-nostemma pentaphyllum Makino, produced a marked inhibitory effect on the lipid peroxidation either spontaneously or induced by Fe2+-cystein, Vit C-NADPH and CCl4. The inhibitory effect was found to be stronger than that of Ginsenosides. GP also resisted the decrease of fluidity of liver microsomal and mitochondrial membrane induced by Fe2+-cystein.
