THE PROTECTIVE EFFECT OF SANCHINOSIDE D_1 ON ACUTE CEREBRAL ISCHEMIA IN RABBITS
- VernacularTitle:三七皂甙D_1对家兔急性脑缺血的保护作用
- Author:
Linxian LI
;
Zican WANG
;
Yingying LI
- Publication Type:Journal Article
- Keywords:
Sanchinoside D1;
Cerebral ischemia;
LDH;
CPK;
EEG
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Acute in-complete cerebral ischemia were induced in 39 rabbits by hypotension coupled with hypoperfusion for 60 min, and acute forebrain ischemia were induced in other 15 rabbits by 4A-Occlus-ion for 30 min followed by reperfusion 120 min. At the end of experiment, EEG, the tissue contents of sodium,potassium and water in the cerebral cortex, the activities of LDH and CPK in the cerebral venous blood and the maximal bleeding volume were estimated. Sanchinoside D1 ( 50mg/kg, i.v.) could ameliorate significantly all the changes of relevant parameters mentioned above in model animals. It was suggested that Sanchinoside D1 had some protective effect on acute cerebral ischemia in rabbits
