EFFECTS OF TETRANDRINE AND NEFERINE ON THE PHENYLEPHRINE-INDUCED CONTRACTIONS IN RAT AORTIC RINGS
- VernacularTitle:粉防己碱和甲基莲心碱对大鼠离体胸主动脉环收缩的影响
- Author:
Wei YAO
;
Quanying ZHU
;
Dingfeng SU
- Publication Type:Journal Article
- Keywords:
Aortic rings;
Phenylephrine;
Tetrandrine;
Neferine
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of tetrandrine and neferine on the phenylephrine-induced contractions were studied in Sprague-Dawley rat aortic rings. It was found that both tetrandrine and neferine ( 2?10-5 mol/L ) markedly inhibited phase I ( release of intracellular calcium) and phase II (entry of extracellular calcium) contractions after a 20 min incubation. After a shorter incubation period, tetrandrine and nefrine inhibited only the phase II contractions. Compared with tetrandrine, neferine exhibited slower and weaker effects
