COMPARISON OF EFFECTS OF DIFFERENT OPIOID ANTAGONISTS ON SCALD SHOCK IN RATS
- VernacularTitle:静脉注射不同阿片肽拮抗物抗大鼠烫伤休克效果的比较
- Author:
Baocheng LIN
;
Xinru HONG
;
Chenghai WANG
;
Henian ZHU
- Publication Type:Journal Article
- Keywords:
Anti-?-endorphin serum;
Naloxone;
TRH;
ICI174864 Scald shock;
Cardiovascular funtion
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Indexes of cardiovascular function and survival time were obser-vedin rats given the following antagonists respectively after scald injury: anti-p-endorphin serum at 10?l, Naloxone at 2mg, ICI174864 at 0.2mg, or TRH at 2 mg, and half of the doses were administered at 1, 2, 3h after scald. The results showed that the cardiac indexes (dP/dtmax, -dP/dtmax and LVSP)were improved, the decrease of mean arterial pressure ( MAP ) and heart rate ( HR ) were delayed after the injections of anti-p-endorphin serum, naloxone or ICIi748e4, and survival time was significantly prolonged in anti ? - endorphin serum group. TRH had little effect on cardiac indexes, MAP and HR were maintained at high level at earlier period, but sharply sloped down in about 210 min after burn. The result suggests that intraventri-cular administration of anti-?-endorphin, naloxone or ICI174864 had much benefit on scald shock, but TRH was uncertain at least in the treatment of scald shock.
