THE EFFECTS OF THYROID HORMONES ON ?ADRENO-CEPTOR NUMBERS IN MOUSE BRAIN
- VernacularTitle:甲状腺激素对小鼠脑?-肾上腺素能受体的影响
- Author:
Xiaoli ZHANG
;
Jianying DONG
;
Yali XU
;
Ziyu LI
- Publication Type:Journal Article
- Keywords:
Thyroid hormones;
?adrenoceptor;
Radioligand binding method;
Rehmannia
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Thyroid hormones are known to influence the activities of sympathetic nerve by modifying the P-adrenoceptor numbers in several peripheral organs. In order to find out whether similar changes exist in central nervous system ( CNS ) , the changes of ?-adrenergic re-cetors in mouse brain during experimental hyperthyroidism and the effects of some Yin Tonice( Rehmannia ) on that were investigated by method of radioligand binding. The results were as follows: 1 . The maximum Binding capacity (Bmax ) value of hyperthyroid mouse brain was 29% higher than the control's. No significant difference in KD value between the control and hyperthyroid animals was found . 2. By administration of rehmannia, the Bmax of hyperthyroid mouse was reduced to control value.
