Modulation of Vagal Afferent Stimulation on High Frequency Oscillation in Phrenic Nerve
- VernacularTitle:选择性迷走神经传入刺激对膈神经高频振荡的调制作用
- Author:
Wenjun YUAN
;
Weijun FU
;
Baowang ZHU
- Publication Type:Journal Article
- Keywords:
high frequency oscillation;
vagal afferent stimulation;
power spectrum;
phrenic nerve
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the role of the vagal afferents in the generation and formation of high frequency oscillation (HFO), effect of selective electrical stimulation of A?-? afferent fiber groups of the vagus nerve (0.4-0.5 V, 0.1ms, 5-160 Hz), applied at three respiratory phases: inspiratory phase (IS), expiratory phase (ES), and continuous phase throughout both IS and ES (CS), on the phrenic HFO was quantitatively assessed on ether-anesthetized, vagotomized, paralyzed and artificially ventilated rabbits. After calculation of the power spectrum of the efferent phrenic nerve activity, the mean square values (MSV), representing total amount of HFO-output, and the peak frequency of the HFO were estimated by means of curve-fitting method. Regardless of the mode of the stimulation, the MSV decreased in a stimulus-frequency dependent fashion. The CS was most potent, then IS, and ES was less effective, though the reduction was significant (p
