Inhibitory Effects of Cicletanine and Bepridil on the Contractions of Isolated Rat Thoracic Aorta Rings
- VernacularTitle:Cicletanine与Bepridil对大鼠离体胸主动脉环收缩的抑制效应
- Author:
Quanying ZHU
;
Wei YAO
;
Dingfeng SU
- Publication Type:Journal Article
- Keywords:
antihypertensive drugs;
antiarrhythmic drugs;
aorta rings;
bepridil;
cicletanine;
potassium chloride;
norepinephrine
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The inhibitory effects of cicletanine (Cic) and bepridil (Bep) on norepinephrine (NE)-and KCl-induced contractions were studied in isolated thoracic aorta rings of male Sprague-Dowley rats. It was found that Cic had a more potent effect on NE-induced contraction than on KCHnduced contraction. In. contrast, Bep had a more potent action on KCHnduced contraction. When the aorta rings were incubated with Cic and Bep, a potentialized inhibitory effect was observed on KCh but not NE-induced contractions. These effects were independent of the presence of endothelium. The results suggest that Cic and Bep have different action sites and properties on vascular smooth muscles.
