Effect of Low and High-Dose GABA from Unpolished Rice-Germ on Timing and Quality of Sleep: A Randomized Double-Blind Placebo-Controlled Trial.
- Author:
Yu Yong SHIN
1
;
Jung Ick BYUN
;
Sung Eun CHUNG
;
Min Ji SEONG
;
Han Ah CHO
;
Hyun Keuk CHA
;
Won Chul SHIN
Author Information
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords: Insomnia; GABA; Unpolished rice; Sleep quality
- MeSH: Actigraphy; Adult; Bacteria; Blood Pressure; Diagnostic and Statistical Manual of Mental Disorders; gamma-Aminobutyric Acid*; Humans; Lactic Acid; Prospective Studies; Sleep Initiation and Maintenance Disorders; Therapeutic Uses
- From:Journal of Sleep Medicine 2016;13(2):60-66
- CountryRepublic of Korea
- Language:Korean
- Abstract: OBJECTIVES: Gamma-aminobutyric acid (GABA) has potential benefits in counteracting the sleep disruption and potential therapeutic effects on blood pressure, stress, cancer, and inflammatory diseases. Recently, High-dose GABA can be extracted from fermented rice germ using lactic acid bacteria. This study aimed to evaluate the effects of GABA natural extracts from fermented rice-germ on sleep latency, subjective sleep quality and insomnia symptoms. METHODS: This was a prospective randomized double-blind placebo-controlled trial performed at Kyung-Hee University hospital at Gangdong from June 2013 to October 2013. Adult (age≥30) patients who was diagnosed of insomnia according to DSM-IV criteria was enrolled. They were randomized into three groups: high dose treatment group 300 mg; low-dose treatment group, 100 mg; and placebo group. Questionnaires including Insomnia Severity Index (ISI), Pittsburgh Sleep Quality Index (PSQI), WHO-5 Well-Being Index were performed, and 1-week actigraphy was recorded before and 1 week after the treatment. RESULTS: Total of 114 patients were randomized into 3 groups: high-dose treatment (n=37), low-dose treatment (n=38), and placebo treatment group (n=39). At 1 week after the treatment, PSQI total score and C2 (sleep latency) score significantly decreased in low-dose and high-dose treatment group than the placebo groups [Repeated measures analysis of variance (ANOVA), p=0.017, 0.004 respectively]. ISI score also decreased in the two groups in dose-dependent manner (Repeated measures ANOVA, p=0.037). There were five (4.4%) patients who reported medication adverse events. CONCLUSIONS: This study suggests that treatment of low and high-dose GABA from unpolished rice-germ decreases sleep latency and improve insomnia severity without severe adverse events.
