STUDY OF THE EFFECT OF DAURICINE ON PLATELET AGGREGATION AND ITS MECHANISM
- VernacularTitle:蝙蝠葛碱对血小板聚集性的影响及其机理研究
- Author:
Yaoxian DING
;
Jian ZHOU
;
Xueming YE
- Publication Type:Journal Article
- Keywords:
Dauricine;
Platelet aggregation;
Throraboxane;
Prostacyclin;
cAMP
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The effect of dauricine on platelet aggregation and its mechan-ism have been studied in the patients and in rabbits. Dauricine inhibited platelet aggregation induced by ADP and generation of thromboxane B2 significantly, but had no effect on plasma 6-keto-PGF1a concentrations in the patients. It did not influence the levels of cAMP of platelets and plasma in rabbits. Its property of antipla-telet aggregation may relate to the influence on arachidonic acid metabolism.
