THE PHARMACOLOGICOL STUDY ABOUT ANTIDEPRESSANT EFFECTS OF THE 7903
- VernacularTitle:3,4—二氯苯丙烯酰另丁胺抗抑郁作用的药理研究
- Author:
Shuxin LI
;
Baoshan KU
- Publication Type:Journal Article
- Keywords:
Antidepressants;
Analogue of piperine;
Tail-suspension test, Forced-swimming test, Hypothermia induced by reserpine
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The antidepressant effects of the N-Isosuccinyl-dichlorocinnamo-ylamide ( 7903 ) , an analogue of piperine, upon 5 animal models were studied. The 7903 was found to have antidepressant effects on the models with doses less than TD50. The 7903 with the single dose, which did not increase the spontaneous motor activity of animals, could significantly decrease the duration of immobility of mice and rats in the forced-swimming test and that of mice in the tail-suspension test. The duration of the longest permanent immobility indaced by cornea electro-stimulation in mice was also decreased with the chronic administration ( 2 weeks ) of the 7903. And the hypothermia induced by reserpine could be antagonized by the 7903.
