VERAPAMIL IMPROVES LOCAL CEREBRAL BLOOD FLOW AND BRAIN WATER CONTENT AFTER CEREBRAL ISCHEMIA IN GERBIL
- VernacularTitle:维拉帕米改善实验性沙土鼠脑缺血后LCBF和脑水份含量
- Author:
Chen ZHANG
;
Shirao BAO
;
Heqin ZHAO
- Publication Type:Journal Article
- Keywords:
Calcium channel blocker;
Cerebral ischemia;
Local cerebral blood flow;
Mongolian gerbil;
Verapamil
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The gerbil model in this study was induced by 30 min of bilateral carotid occlusion and 120 min of reperfusion. Verapamil ( 0.5 mg/kg)was given intravenously 10 min before ischemia, or 5 min after bilateral carotid occlusion. Local cerebral blood flow was determined by the hydrogen clearance teachnique. Brain water content was detected by the wet and dry methods. We conclude that verapamil used in this model may improve post-ischemic hypo-perfusion, increase local cerebral blood flow in ischemic region (P
