MORPHINE INCREASES THE BEATING RATE IN CULTURED RAT HEART CELLS
- VernacularTitle:吗啡加快体外培养乳鼠心肌细胞的搏动频率
- Author:
Jianguang CHEN
;
Su MA
;
Xinying CUI
- Publication Type:Journal Article
- Keywords:
Morphine;
Naloxone;
Cultured heart cells;
Beating rate
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
At the concentrations of 10-8mol/L, 5.5?l0-8mol/L, 10-7mol/L morphine produced a dose-dependent increase of beating rate in cultured rat heart cells with 9%,32%and 81% respectively. The increase was antagonized by opiate antagonist naloxone ( 10-5mol/L ) , but not affected by propranolol ( 10-5mol/L ) which could cancel the positive chronotropy of isoprenaline ( 10-9mol/L ) on the beating cells. The results support the concept that morphine may be a direct effect on myocadium, perhaps through opiate receptors.
