PRELIMINARY REPORTS OF THE STUDIES ON ANTIHYPOXIA MECHANISM OF 18?-SGA
- VernacularTitle:18?-甘草次酸钠抗缺氧机理的初步探讨
- Author:
Mingzhu GE
;
Zhilin ZHANG
;
Xingbin PAN
- Publication Type:Journal Article
- Keywords:
18?-SGA;
Hypoxia;
Antihypoxia;
Disbalance of acid-base;
Thyroxine
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The studies on the antihypoxia mechanism of 18?-SGA were reported. The survival time of hypoxia mice were longer than those of the control after intraperitoneal injections of 14mg/kg or 21mg/kg of 18?-SGA ( Sodium 18?-glycyrrenetic acid). Changes of various physiological indications after administration of the drug were as follows: blood pH was risen; acidosis was relieved; and the partial pressure of oxygen in the mixed blood was decreaed. The blood thyroxine level remain unchanged. It suggests the utilization of oxygen by the tissues was strengthened.
