STUDIES ON ANTI-ULCER EFFECT OF DICARBOXYETHYL GERMANIUM SESQUIOXIDE AND ITS MECHANISMS OF ACTION
- VernacularTitle:二羧乙基锗倍半氧化物的抗大鼠实验性胃溃疡作用及其作用机理研究
- Author:
Jingji JIN
;
Shihao PIAO
;
Wenlong FANG
;
Zhutian LI
- Publication Type:Journal Article
- Keywords:
Gastric ulcer;
Prostaglandin;
Germanium;
Pepsin
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Dicarboxyethyl Germanium Sesquioxide ( DEG ) is a organic germanium compound of artificial synthesis. It could inhibite gastric lesions in pylorus-tightened rats, increased the levels of PGE2 and markedly reduced pepsin activity and free acid of gastric juice. DEG also inhibited formation of indomethacine, pentagastrin and alcohol induced ulcer. It could accelerate the healing of acetic acid ulcer, but couldn't against acute stress and reserpin produced gastric ulcer. The secretory reaction of chief cell of DEG groups were reduced markedly than control. To sum up, the prineiple mechanism of anti-gastric ulcer of DEG may be by raising the levels of PGE2 in gastric juice and inhibiting pepsinia and promoting synthesis of protein.
