THE CHANGES OF TXB_2 AND 6-Keto-PGF_(1a) CONCENTRATION IN PLASMA AND LUNG LYMPH IN ENDOTOXIN-INDUCED LUNG INJURY IN CONSCIOUS SHEEP
- VernacularTitle:清醒绵羊内毒素急性肺损伤血浆及肺淋巴液血栓素及前列环素的变化
- Author:
Jinkai CHEN
;
Bin SUN
;
Yunkui ZHU
- Publication Type:Journal Article
- Keywords:
Endotoxin Lung injury Lung lymph fistula Thromboxane Prostaglandin
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
We observed the pulmonary responses and changes in TXB2 and 6-keto-PGF1a concentrations in plasma and lung lymph in endotoxin induced lung injury. The typical pulmonary responses appeared after the injury. The TXB2 concentrations in plasma and lung lymph increased by 24.5 and 30.7 times and those of 6-keto-PGFla by 10.6 and 15.7 times, respectively, as compared with baseline. The TXB2 and 6-keto-PGF1a concentrations in lymph were 68 and 75 percent higher than those in plasm a respectively. The results indicated that TXA2 and-PGI2 synthesis increased in the lung after injury and that TXA2 and PGI2 were important media in the lung injury.
