THE PREVENTIVE EFFECT OF GARLIC AGAINST TOXICITY OF DIMETHYLNITROSAMINE IN RATS FED WITH AMINOPYRINE AND NITRITE
- VernacularTitle:大蒜对氨基比林与亚硝酸钠在大鼠体内所致毒性的预防作用
- Author:
Xiyun LIN
;
Lianping LI
;
Qichen ZHANG
;
Xing MEI
- Publication Type:Journal Article
- Keywords:
garlic aminopyrine nitrite dimethylnitrosamine liver injuryDepartment of Pathology, Shandong Medical University
- From:
Acta Nutrimenta Sinica
1956;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The preventive effect of garlic against toxicity of dimethylnitrosamine (NDMA) in rats medicated with aminopyrine (AP) and NaNO2 was investigated. 28 rats were divided into three groups. The 6 rats of group C were set as control taking basal diet; the 10 rats of group B were given basal diet, AP, and NaNO2; the 12 rats of group A were given basal diet with an addition of 10% of garlic, AP and NaNO2. AP and NaNO2 in the dosage of 30 mg per kg of body weight were dissolved in 0.5% acetic acid and given by gavage to rats of groups A and B.During the experimental period of 35 days, 3 rats of group B died while all the rats of group A survived. At the end of the experiment, Hb, SGPT and SGOT were determined and all rats were killed for pathological studies. It was found Hb value of group A was higher than that of group B (P
