The Effects of Carbamates and Soman on the Metabolism of Nicotinic Acetylcholine Receptors in Cultured Skeletal Muscle Cells
- VernacularTitle:氨基甲酸酯类药物和梭曼对N乙酰胆碱受体代谢的影响
- Author:
Xin WANG
;
Qingwu MAO
- Publication Type:Journal Article
- Keywords:
cholinergic receptros;
cholinesterase inhibitors;
carbamates;
soman
- From:
Academic Journal of Second Military Medical University
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of carbamates and soman on the metabolism of nicotinic acetylcholine receptors (N-AChR) in cultured skeletal muscle cells were studied by 125I-a-bungarotoxin (125I-a-BTX), a specific marker. It was indicated that N~AChR degradation process was inhibited and the incorperation rate of IshAChR and the number of N~AChR in the surface of the cell membrane were increased 4h after prertreatment of high concentrations of carbamates. The number of N-AChR was also increased after pre-treatment of low concentrations of soman, whose effects on N-AChR metabolism were similar to those of high concentrations of carbamates. The incorperation rate of N-AChR was observed by inhibiting the protein synthesis with puromysin, suggesting that soman may increase the number of N-AChR by increasing the incorperation of N-AChR instead of increasing the synthesis of N-AChR.
