EFFECTS OF OLEANOLIC ACID ON PROSTA6LANDINS AND CYCLIC NUCLEOTIDE
- VernacularTitle:齐墩果酸对前列腺素及环核苷酸的影响
- Author:
Jun REN
- Publication Type:Journal Article
- Keywords:
Oleanolic acid;
Prostaglandin E_2;
Prostaglandin F_2?;
cAMP;
cGMP;
Histamine
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Effects of oleanolic acid on immunoregulation were investigated in mice on the molecular level. Results showed that oleanolic acid could stimulate the biosynthesis or release of prostaglandins E2, F2? ( PGE2, PGF2? ) and cAMP, whereas had an inhibitory action on cGMP and histamine. Prostaglandins, cyclic nucleotides and histamine participate in many bodily functions, including regulation of blood pressure, immune function. It is suggested that their interaction may be of potential importance as a possible mechanism by which oleanolic acid acts in disease.
