EFFECTS OF PANAX NOTOGINSENG SAPONINS ON MYOCARDIAL ISCHEMIA AND REPERFUSION INJURY IN CONSCIOUS RABBIT
- VernacularTitle:三七总皂甙对清醒兔心肌缺血再灌注损伤的保护作用
- Author:
Cong HUANG
;
Tianxiang GU
;
Yongyuan GUAN
;
Jinqun WANG
- Publication Type:Journal Article
- Keywords:
Panax notoginseng;
Saponins;
Myocardial ischemia;
Reperfusion injury.
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of Panax notoginsen saponins ( PNGS ) on myocar- dial ischemia and reperfusion injury in conscious rabbit were studied with observation of changes in electrocardiogram (ECG), the activities of creatine phosphokinase ( CPK ) and lactate dehydrogen-ase ( LD ) and the size of ischemic area. 50 mg/kg and 100 mg/kg PNGS significantly decreased the activities of CPK and LD, and the abnormal changes of ECG during ischemic and reperfusion periods. Also, PNGS significantly reduced the size of myocardial ischemic area. These results suggest that PNGS have the protective effects on myocardial ischemia and reperfusion injury.
