EFFECTS OF TAURINE, QUINIDINE AND THEIR COMBINATION ON EXPERIMENTAL ARRHYTHMIAS INDUCED BY ACONITINE IN MICE
- VernacularTitle:牛磺酸、奎尼丁及两药联合应用抗小鼠实验性心律失常的作用
- Author:
Yi KANG
;
Yiyan WU
;
Guoxiang WANG
- Publication Type:Journal Article
- Keywords:
Taurine;
Quinidine;
Aconitine;
Arrhythmia
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The constant iv. of aconitine can induce the varied arrhythmias in mice. Taurine 100mg/kg iv. or Quinidine 5 mg/kg iv. can delays the onset time of arrhythmias, and increases the dose of aconitine, respectively .But no effects were seen in mice pretreated with taurine 50mg/kg or quinidine 2.5mg/kg. However their combination can significantly decrease the incident of ventricular fibrillation and delay the onset time of death. Our results suggested that taurine, quinidine and their combination are effective on arrhythmias induced by aconitine in mice.
