INFLUENCE OF bPTH ( 1-34 ) ON PGI_2 RELEASE FROM HEART CELLS
- VernacularTitle:甲状旁腺激素对心肌细胞PGI_2释放的影响
- Author:
Yibin ZHANG
;
Zhengang WANG
;
Jingxuan CHEN
- Publication Type:Journal Article
- Keywords:
bPTH (1-34), Heart cells, Calcium inophone A23187, Verapamil, PGI_2, 6-keto-PGF_(1?)
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
In order to explore the mechanism of cardiac damage by PTH, the release of PGI2 from heart cells was measured. The results showed that bPTH ( 1-34) increased the release of 6-keto-PGFla from heart cells in a dose dependent manner. Calcium inophone A23187 also increased the 6-keto-PGF1? release, while EDTA and verapamil reduced it. These suggest that the PGI2 synthesis in heart cells was affected by intra and extracellular calcium. The significance of bPTH( 1-34) induced increase of PGI2 synthesis might be associated with interference of energy metabolism, and then, cell damage.
