EFFECTS OF METOCLOPRAMIDE ON PHYSIOLOGIC PROPERTIES OF GUINEA PIG PAPILLARY MUSCLES AND HEMODYNAMICS IN DOGS
- VernacularTitle:胃复安对豚鼠心肌生理特性及犬血液动力学的作用
- Author:
Xiaodong LU
;
Dongke ZHAO
;
Gengsheng ZHAO
- Publication Type:Journal Article
- Keywords:
Metoclopramide;
Guinea pig papillary muscle;
Contractility;
Cardiac hemodynamics
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of metoclopramide( MCP ) on the physiologic properties of guinea pig papillary muscles and the hemodynamics in anesthetic dogs were studied. MCP decreased contractility, increased the epinephrine concentration inducing automaticity and shifted the voltage-time plot to the right. But the functional refractory period was prolonged. Furthermore, the contractility and automaticity of the right auricle were decreased. MCP 5 mg/kg iv increased cardiac index (CI), systolic blood pressure ( SBP ), diastolic blood pressure ( DBP ), left ventricular systolic pressure ( LVSP ), maximal rate of change of intraventricular pressure ( dP/dtmax ), and total peripheral resistance ( TPR ) while MCP 10mg/kg iv decreased SBP, DBP, LVSP, dP/dtmax and TPR except increase of CI.
