THE MECHANISM OF DEXAMETHASONE EFFECT ON RABBIT PLATELET AGGREGATION AND RELEASE
- VernacularTitle:地塞米松影响血小板聚集、释放机理的探讨
- Author:
Zhixian MO
;
Yuehua HUANG
;
Xingfang LI
- Publication Type:Journal Article
- Keywords:
Dexamethasone;
Platelet;
PLA2;
TXA2
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The effect of dexamethason ( Dex ) on the rabbit platelet aggregation and release was studided. The results were showed that the platelet aggregation and release induced by collagen were inhibited markedly by Dex, TXA2 production of platelets also reduced, but the platelet activation induced by AA was not affected by Dex. The results were further showed that the PLA2 activity was depressed by Dex, and the action of Dex can be antagonized partly by increase of extracellular Ca2+, it suggests that Dex inhibited the activity of PLA2 with the reduction of Ca2+ inflow into cell. The activity of CaM and AC, the production of cAMP and cGMP were not affected by Dex.
