THERAPEUTIC EFFECTS OF BHGF ON ACUTE HEPATIC FAILURE INDUCED BY D-GALACTOSAMINE IN RATS
- VernacularTitle:新生牛肝细胞生长因子对大鼠急性肝衰竭影响的初步研究
- Author:
Jiulong JU
;
Jiazhang XU
;
Cen DING
- Publication Type:Journal Article
- Keywords:
BHGF;
AHF;
D-Gal
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The therapeutic effects of bovine hepatocytic growth factor ( BHGF ) were studied on acute hepatic failure ( AHF ) induced by D-galactosamine ( D-Gal ) in rats. The BHGF was isolated from the hepatic cytosol of newborn cow in our laboratory and its molecular is under 20 000 dalton. The results showed that. l)the survival rate of the rats with AHF was significantly enhanced after therapy with BHGF, 2 ) the 8H-TdR were highly incoporated into hepatocytic DNA of the rats, 3 ) the pathological damage of the rat liver was obviously improved, when comparied with the control. It is Suggested that BHGF could stimulate the hepatocytic DNA synthesis and be effective in the therapy of AHF in rats.
