EFFECTS OF NAPHTHYLMETHYL ISOQUINOLINE ON CONTRACTILE TENSION AND VOLUME OF OXYGEN CONSUMPTION IN HEART MUSCLES
- VernacularTitle:萘甲异喹对心肌收缩张力和耗氧量的影响
- Author:
Wei ZHANG
;
Yuling YANG
- Publication Type:Journal Article
- Keywords:
Naphthylmethyl isoquinoline;
Contractile tension;
Volume of oxygen consumption;
Verapamil;
Calcium-antagonist
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of naphthylmethyl isoquinoline (NI) and verapamil (Ver) on contractile tension and volume of oxygen consumption were compared on isolated guinea pig left atrips and cat papillary muscles. The results showed that NI and Ver diminished the Ca++-dependent contractile tension and volume of oxygen consumption by electrically driven preparations. Under the influence of increasing doses of NI (10 ~100?mol/L)and Ver(0.72~3.6?mol/L) linear reduction of contractile tension and volume of oxygen consumption were seen. These effects were reversed by increasing the extracellular Ca++ concentration. These results indicate that NI may be an effective calcium-antagonist very similar to Ver.
