THE EFFECTS OF ?-ELEMENE ON DNA-BINDING SPECIFICITY AND RNA POLYMERASE INHIBITORY ACTIVITY
- VernacularTitle:?-榄香烯对RNA聚合酶活性的抑制及与DNA的结合
- Author:
Xiuyun CUI
;
Deshan LI
- Publication Type:Journal Article
- Keywords:
?-elemene;
RNA polymerase;
Tm of DNA;
Intensity of fluorescence of DNA
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
?-elemene that is an element of the Essential oil of the Cuicu-ma Wenyujin showed appreciable anticancer ability. The experimental results showed that the RNA polymerase activity was inhibited by ?-elemene at concentrations of 0.0074 mol/L~0.0172 mol/L. The study of thermal denaturation indicated that the Tm of DNA was decreased after adding ?-elemene. The fluorescent analysis of ?-elemene bound to DNA showed that the intensity of fluorescence was increased. The peak of absorption of DNA was shifted from 260 nm to 240 nm after treatment with ?-elemene.
