DETECTION OF PRE-S2 PROTEIN IN THE KIDNEY IN PATIENTS WITH GLOMERU-LONEPHRITIS
- VernacularTitle:肾炎病人肾组织中乙型肝炎病毒前-S_2蛋白的检测及意义
- Author:
Jinghong ZHANG
;
Hong ZHOU
;
Leishi LI
- Publication Type:Journal Article
- Keywords:
Pre-S2 protein Hepatitis B virus Kidney glomerulonephritis
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The presence of pre-S2 protein in the kidney was investigated in 30 patients with biopsy-proved glomerulonephritis (GN) using indirect immunoperoxidase technique and monoclonal antibody. HBsAg and HBeAg in the kidney were detected using the same techniques and HBsAg, HBeAg, anti-HBs, anti-HBe and anti-HBc in serum were assayed at the same time.It was shown that pre-S2 prtein was present in the kidney in 7/22 patients with primary GN and 6/8 with lupus nephritis. It was deposited along the glomerular capillary walls or within the mes-angium, depending on the type of GN as well as the deposition of immunoglobulins and complement components in the kidney. Deposition of pre-S2 protein in renal tissue was correlated with HBsAg deposition in the glomeruli, but not HBeAg deposition. In membranous GN, there was a good correlation between the presence of pre-S2 protein in the kidney and virus antigetiemia. It is concluded that pre-S2 protein detection in the kidney is of value in evaluating the hepatitis B virus associated GN.
